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Ippei Kawano


Why the Colon Must Stay Anoxic
What is the function of the colon? The current understanding is surprisingly narrow in scope. Once food passes through the small intestine and reaches the colon, most digestible macronutrients have already been absorbed. The structural features also change from the ileum to the colon in a way that suggests functional divergence. The ileal lumen has features that increase surface area (circular folds, villi, and brush border) for efficient nutrient absorption. This area-maximi
Ippei Kawano
Mar 216 min read


Insulin Resistance — Medicine’s Systemic Blindness
Insulin — the most important hormone There is a silent epidemic in much of the industrialized world. As our lives become modernized, our nutrition and hygiene improve, and our knowledge of medicine enables the early detection and treatment of an increasing number of pathologies, a novel illness also creeps in. Completely asymptomatic for years, even decades, by the time it manifests, it has morphed into a monstrous entity, well beyond the reach of even the most advanced thera
Ippei Kawano
Oct 29, 202512 min read


Clinical Medicine is Bayesian
The Doctor, an 1891 portrait by Luke Fildes ( Wikipedia ) Based on what information do physicians make decisions? We would like to think...
Ippei Kawano
Sep 13, 202515 min read


The Goose That Laid the Age of Reason
Jan Hus, Czech Secularism, and the Forgotten Christian Roots of Modern Individualism If you wander through the beautiful streets of...
Ippei Kawano
May 10, 202511 min read


The Elegant Chemistry of the Krebs Cycle
Dedicated to all the medical students who never understood what was going on... In the human body, the main job of the Krebs cycle is to...
Ippei Kawano
Feb 19, 20255 min read


Brain-centered regulation of physiology
Vagus hotline One of the most fascinating reports from last year came from Charles Zucker's team regarding the interaction between the...
Ippei Kawano
Jan 14, 20253 min read


Cash Therapy
Complaints from Ph.D. holders about poor job prospects have become increasingly common these days. Indeed, a Ph.D. is the most advanced...
Ippei Kawano
Oct 24, 20243 min read


Acetylation and aging
For a very long time, aging was considered to be largely the result of wear and tear accumulating over a lifetime — be it free radicals,...
Ippei Kawano
Sep 13, 20245 min read


Lactate — the misunderstood "acid"
“Lactic acidosis” is among the more basic clinical concepts taught in medical school, but this term is hugely misleading. In our uni’s...
Ippei Kawano
Sep 13, 20242 min read


Why do neurons adapt? Or, the art of making acronyms
To be verbally descriptive is to be informationally inefficient. All that space, time, and cognitive effort wasted on words! Most books...
Ippei Kawano
Sep 13, 20246 min read
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